Multi-modal ion-exchange membranes for rapid separations
AssigneeClemson University Research Foundation
InventorJinxiang Zhou
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Abstract
Ion exchange membranes (e.g., anion exchange membranes) and methods of using the membranes are described. The ion exchange membranes are multi-modal ion exchange membranes containing a plurality of multi-modal exchange ligands. The membranes can achieve high dynamic and equilibrium binding capacities at solution conductivities typical for production of biologics (e.g., greater than about 10 mS/cm) and can provide excellent binding at high flow rates. Systems incorporating the membranes can dramatically increase isolation and purification speeds. Membranes are disclosed for use in production of biologics.
Claims19
A multi-modal ion exchange membrane comprising:
- a porous membrane substrate;
- a plurality of polymers grafted at a surface of the porous membrane substrate;
- and
- a plurality of ligands bonded to and pendant from each of the grafted polymers, each of the ligands that is bonded to and pendant from each grafted polymer providing first and second modes of sorptive functionality, the first mode of sorptive functionality being an ionic fixed charge at a binding site linking the ligand with the grafted polymer to which it is bonded to and pendant from, the second mode of sorptive functionality being a component of the ligand that is bonded to and pendant from the grafted polymer.
Dependencies are inferred from the claim text.