Implant with antiproliferative active substance limited to abluminal side and method of production

An implant, consisting of:

• a degradable main body defining a lumen, wherein the main body consists of a magnesium degradable alloy;
• a degradable coating comprising at least one degradable polymer, the degradable coating substantially completely enclosing the main body on its luminal and abluminal sides;
• and
• an antiproliferative active substance consisting only of the antiproliferative active substance itself applied upon the degradable coating only on the abluminal side of the main body, wherein the degradable coating contains no active substance and the antiproliferative active substance is not in mixture with the degradable coating, wherein the antiproliferative active substance is paclitaxel or an mTOR inhibitor, wherein the mTOR inhibitor is selected from one of the following
• sirolimus;
• everolimus;
• zotarolimus
• temsirolimus;
• biolimus A9
• ridaforolimus;
• or
• a compound according to formula I, wherein formula I is
• in which R is C(O)—(CH2)n-X, n is 0, 1 or 2, and X is a cyclic hydrocarbon having 3-9 carbon atoms, which optionally contains one or more unsaturated bonds.