Shape memory adhesive materials for diabetic wound healing
AssigneesMassachusetts Institute of Technology, Beth Israel Deaconess Medical Center, Inc.
InventorsXuanhe Zhao, Hyunwoo Yuk, Heejung Roh, Aristidis Veves, Georgios Theocharidis
Life of this patent
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Abstract
A shape memory adhesive material for adhering and contracting wounds, particularly diabetic wounds, to facilitate their closure and healing. The shape memory adhesive is pre-stretched and dried to provide an adhesive structure with a pre-programmed strain, wherein the adhesive is capable of rapid robust adhesion followed by predictive contraction upon contact with a wet surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.
Claims40
A method of healing a wound comprising:
- applying a dry shape-memory adhesive material to a tissue surface surrounding the wound, the dry-shape-memory adhesive having a dry pre-stretched configuration, the tissue surface having fluid disposed thereon;
- and
- allowing the dry pre-stretched shape-memory adhesive material to absorb at least a portion of the fluid and transform to a hydrated rubbery state to trigger (i) hydration-based adhesion to the tissue surface surrounding the wound and (ii) contraction of the shape memory adhesive material from the dry-pre-stretched configuration,
- wherein the dry shape-memory adhesive material comprises one or more hydrophilic polymers, one or more amine coupling groups, and one or more cross linkers.
A method of healing a diabetic wound comprising:
- applying a dry shape-memory adhesive material to a tissue surface surrounding the diabetic wound, the dry-shape-memory adhesive having a dry pre-stretched configuration, the tissue surface having fluid disposed thereon;
- and
- allowing the dry pre-stretched shape-memory adhesive material to absorb at least a portion of the fluid and transform to a hydrated rubbery state to trigger (i) hydration-based adhesion to the tissue surface surrounding the diabetic wound and (ii) contraction of the shape memory adhesive material from the dry-pre-stretched configuration,
- wherein the dry shape-memory adhesive material comprises one or more hydrophilic polymers, one or more amine coupling groups, and one or more cross linkers.
Dependencies are inferred from the claim text.