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US 12,485,192 B2Granted
Cellular targeted label delivery system
AssigneeCellis AG
InventorsMagdalena Krol, Irene Benni, Paola Baiocco, Tomasz Rygiel, Alberto Boffi
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Abstract
The present invention relates to an isolated cellular targeted delivery system comprising a CD45+ leukocyte cell comprising within said cell a complex of one or more iron binding proteins and/or a label as well as methods for producing such isolated cellular targeted delivery system and uses of such system for therapy diagnosis and in particular for diagnosis of cancer, particularly metastatic cancer, in particular for therapy of cancer.
Claims12
A method for diagnosing a tumor, comprising:
- (a) administering to a subject in need thereof, a CD45+ leukocyte cell comprising within said cell a complex of ferritin and a radioisotope to diagnose the tumor;
- wherein the CD45+ leukocyte cell is a monocyte or a macrophage;
- wherein the radioisotope is encapsulated by multimers of the ferritin in the absence of a covalent bond;
- and wherein the CD45+ leukocyte cell delivers the radioisotope into tumor cells;
- and
- (b) detecting a concentration of the radioisotope in the tumor cells;
- wherein an increased concentration of the radioisotope in tumor cells, as compared to cells in other regions of the subject's body, provides a diagnosis of a tumor.
4 more elements
Dependencies are inferred from the claim text.