Hepatitis B virus vaccines
AssigneesVir Biotechnlogy, Inc., Triad National Security, LLC
InventorsEric Bruening, Janet Douglas, Emily Marshall, Karina Yusim, Bette Korber, James Theiler
Life of this patent
Estimating the term…
Abstract
Isolated polynucleotides and polypeptides, and hepatitis B virus (HBV) vaccines comprising the same. Viral vectors for expressing such polypeptides, and which may be used in HBV vaccines, as well as methods of protecting a subject from HBV infection and methods of treating HBV in a subject comprising administering the polypeptides, vectors, or vaccines. Methods of designing and producing an HBV vaccine comprising designing vaccine antigens to cover the diversity within a geographic area using an antigen amino acid sequence that efficiently covers the epitopes in the HBV genotypes present in the geographic area.
Claims15
A polypeptide comprising the amino acid sequence as set forth in SEQ ID NO:1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 14 15, 24, 25, or 26.
A polypeptide comprising two or more of the amino acid sequences selected from SEQ ID NOs:1-11, 14, 15, and 24-26.
A cytomegalovirus (CMV) vector comprising a polynucleotide comprising the sequence encoding one or more amino acid sequences as set forth in SEQ ID NO:1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 14, 15, 24, 25, or 26.
Dependencies are inferred from the claim text.