Cancer therapy compositions and uses thereof
AssigneeHDT Bio Corp.
InventorsSteven Gregory Reed, Darrick Albert Carter, Malcolm Scott Duthie, Lars Peter Aksel Berglund, Jesse Hong-Sae Erasmus, Jiho Kim
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Abstract
The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Compositions described herein include lipid carriers, optionally including an inorganic particle, capable of admixing with nucleic acids. Nucleic acids provided herein include those encoding for cancer antigens (full length proteins or fragments) as well as antibodies. Methods of using the compositions as a therapeutic vaccine for the treatment of a cancer are also provided.
Claims26
A composition comprising:
- lipid nanoparticles, wherein the lipid nanoparticles are characterized as having a z-average diameter particle size measurement of about 20 nm to about 60 nm when measured using dynamic light scattering, and wherein the lipid nanoparticles comprise:
- a cationic lipid;
- a hydrophilic surfactant;
- and
- a hydrophobic surfactant;
- and
- at least one nucleic acid, wherein the at least one nucleic acid comprises:
- a sequence encoding for an RNA-dependent polymerase;
- and
- a sequence encoding for a transmembrane-binding domain, an outer cell membrane-contacting domain, and an inner cell membrane-contacting domain of a prostein protein.
Dependencies are inferred from the claim text.