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US 12,485,132 B2Granted
GPX4 inhibitors and senolytic compounds and uses thereof
AssigneeRubedo Life Sciences, Inc.
InventorsMichael Hadd, Paul Keitz
Life of this patent
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Abstract
The present invention relates to compounds that kill senescent cells i.e., senolytic compounds and compounds which inhibit GPX4. The present invention also provides compounds and methods for treating senescence-associated diseases or disorders, and compounds and methods for treating diseases or disorders impacted by GPX4.
Claims10
A compound having the structure:
- or pharmaceutically acceptable salts, hydrates or solvates thereof.
A compound having the structure:
- or pharmaceutically acceptable salts, hydrates or solvates thereof.
A compound having the structure:
- or pharmaceutically acceptable salts, hydrates or solvates thereof.
A compound having the structure:
- or pharmaceutically acceptable salts, hydrates or solvates thereof wherein:
- R1 is cycloalkyl;
- R2 is —H, alkyl, cycloalkyl or —C(O)CH3;
- R3 is R4CO— or R5R6NCO—;
- R4 is cycloalkyl;
- R5 is hydrogen or alkyl;
- and R6 is cycloalkyl.
4 more elements
Dependencies are inferred from the claim text.