Pyrrolo 12.3-dipyrimidine compounds and analogues thereof

A compound represented by Formula (I), or a pharmaceutically acceptable salt thereof:

• wherein:
• R1 represents aryl or heteroaryl;
• wherein:
• each aryl or heteroaryl is:
• substituted by one or more halogens, and
• optionally is substituted with one or more substituents selected from the group consisting of halogen, azide, alkyl, arylalkyl, alkenyl, alkynyl, cycloalkyl, hydroxyl, alkoxy, haloalkoxy, amino, nitro, sulfhydryl, imino, amido, phosphonate, phosphinate, carbonyl, carboxyl, silyl, ether, alkylthio, sulfonyl, sulfonamido, ketone, aldehyde, ester, heterocycloalkyl, aryl, heteroaryl, fluoroalkyl, and cyano;
• R2 and R3 each independently represent H;
• R4 represents optionally substituted alkyl, cycloalkyl, or (cycloalkyl)alkyl;
• wherein:
• each optionally substituted alkyl, cycloalkyl, or (cycloalkyl)alkyl) is optionally substituted with one or more substituents selected from the group consisting of halogen, azide, alkyl, arylalkyl, alkenyl, alkynyl, cycloalkyl, hydroxyl, alkoxy, haloalkoxy, amino, nitro, sulfhydryl, imino, amido, phosphonate, phosphinate, carbonyl, carboxyl, silyl, ether, alkylthio, sulfonyl, sulfonamido, ketone, aldehyde, ester, heterocycloalkyl, aryl, heteroaryl, fluoroalkyl, and cyano;
• X represents CH2;
• Y is absent or represents CH2;
• Ra represents H;
• m is 1;
• n is 1;
• represents
• Z1 represents N;
• Z2 represents CH;
• Z3 represents C;
• Z4 represents CR8;
• Z5 represents N;
• Z6 represents CH;
• Z7 represents N;
• L represents —H, —CN, or —C(O)R7;
• R7 represents NH2;
• and
• R8 represents halogen, —NH2, or —C(O)NH2.