Personal dental care product for caries treatment
AssigneeCredentis AG
InventorsMichael Hug, Dominikus Amadeus Lysek
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Abstract
The present invention provides new dental care products comprising self-assembling peptides that are capable of undergoing self-assembly at a certain pH for use in dental care, e.g. preventing and/or treating a tooth lesion such as a caries lesion, remineralising a tooth surface or increasing smoothness or shine, or for increasing hardness of a tooth surface. The present invention provides dental care products such as chewing gum, toffees or toothpaste, in which the peptides are present in monomeric form for a prolonged period after application into the oral cavity, thereby enabling non-targeted treatment of a plurality of teeth, independent of the diagnosis of an active lesion. Products of the invention are useful for animals and humans.
Claims16
A method for treating a tooth of a subject, comprising applying a dental care product to a plurality of teeth of a subject, wherein the dental care product comprises
- (i) self-assembling peptides comprising the sequence of SEQ ID NO:
- 4 and having at least 80% sequence identity to one of the sequences of SEQ ID NO:
- 1 or 2, wherein the self-assembling peptides are present in the dental care product in monomeric form, and
- (ii) a pharmaceutically acceptable base,
- wherein the pH of the dental care product is not buffered but instead wherein the dental care product is solid with a water content low enough to prevent self-assembly of the self-assembling peptides,
- wherein the dental care product is applied to a plurality of teeth of the subject independent of diagnosis of caries,
- wherein the subject has an early subsurface caries lesion,
- wherein the concentration of self-assembling peptides is 0.1-1000 mg/kg,
- and wherein, after application, self-assembling peptides are present in monomeric state for at least 1 minute.
Dependencies are inferred from the claim text.