Method for assisting evaluation of condition of kidneys, system for evaluating condition of kidneys, and program for evaluating condition of kidneys
AssigneesKagami Inc., National Institutes of Biomedical Innovation, Health and Nutrition
InventorsMasashi Mita, Tatsuhiko Ikeda, Tomonori Kimura
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Abstract
The present invention provides a method for assisting in the evaluation of the condition of kidneys, a system for evaluating the condition of kidneys, and a program for evaluating the condition of kidneys, using, as an index, the ratio of reabsorption of D-serine and/or D-asparagine in target kidneys and excretion of the D-serine and/or D-asparagine. The present invention also provides a method for monitoring the condition of kidneys and a method for monitoring the effect of treatment on kidney disease.
Claims20
A method for assisting evaluation of kidney condition, using the rate of reabsorption and excretion of D-serine and/or D-asparagine in the kidneys of a subject as a marker:
- comprising:
- measuring a rate of reabsorption and excretion of D-serine and/or D-asparagine in the kidney by an enzyme method, chromatography or quantitation by an immunological method;
- wherein the rate is the excretion rate of D-serine into urine of the subject (subject D-serine excretion rate) and/or the excretion rate of D-asparagine into urine of the subject (subject D-asparagine excretion rate);
- and evaluating the kidney condition by comparing the measured rate of reabsorption and excretion of D-serine and/or D-asparagine to a threshold value.
A system for evaluating kidney condition that comprises a storage unit, an input unit, an analytical measurement unit, a data processing unit and an output unit, wherein:
- the storage unit configured to store a threshold value inputted from the input unit, and a calculation formula for D-serine excretion rate into urine and/or a calculation formula for D-asparagine excretion rate into urine, the analytical measurement unit configured to quantify quantifies the D-serine level and/or D-asparagine level in a blood sample and/or urine sample by an enzyme method, a chromatography method or quantitation by an immunological method,
- the data processing unit configured to calculate the D-serine excretion rate and/or D-asparagine excretion rate in urine generated from an element containing the quantified D-serine level and/or D-asparagine level in a blood sample and/or urine sample, and the calculation formula for D-serine excretion rate and/or the calculation formula for D-asparagine excretion rate stored in the storage unit, the data processing unit configured to evaluate kidney condition based on the threshold value stored in the storage unit and the D-serine excretion rate and/or D-asparagine excretion rate in the urine, and the output unit configured to output the evaluation results for kidney condition of the subject.
A program that causes an information processing device comprising an input unit, an output unit, a data processing unit and a storage unit to evaluate kidney condition, wherein the program includes a command programmed to cause the information processing device:
- to store in the storage unit a threshold value for evaluation of kidney condition inputted from the input unit, a calculation formula for a D-serine excretion rate and/or a calculation formula for a D-asparagine excretion rate in urine, and variables necessary for calculation, wherein the D-serine excretion rate and/or the D-asparagine excretion rate in urine is measured by an enzyme method, chromatography or quantitation by an immunological method, and stored in the storage unit as a D-serine level and/or a D-asparagine level in a blood sample and/or urine sample with variables necessary for calculation of the D-serine excretion rate and/or D-asparagine excretion rate in urine, inputted from the input unit, to call the calculation formula for D-serine excretion rate and/or the calculation formula for D-asparagine excretion rate in urine that is prestored in the storage unit, and the D-serine level and/or D-asparagine level in a blood sample and/or urine sample and the variables, which are stored in the storage unit, and substitute them into the calculation formula for D-serine excretion rate and/or the calculation formula for D-asparagine excretion rate in urine to calculate the D-serine excretion rate and/or the D-asparagine excretion rate, in the data processing unit;
- to compare the threshold stored in the storage unit and the D-serine excretion rate and/or the D-asparagine excretion rate in the data processing unit and evaluate kidney condition;
- and to output the evaluation results for kidney condition of the subject to the output unit.
Dependencies are inferred from the claim text.