Tropane alkaloid (TA) producing non-plant host cells, and methods of making and using the same
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsChristina D. Smolke, Prashanth Srinivasan
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Abstract
Provided herein, among other things, is an engineered non-plant cell that produces a tropane alkaloid product, a precursor of a tropane alkaloid product, or a derivative of a tropane alkaloid product. A method for producing a tropane alkaloid, a precursor of a tropane alkaloid product, or a derivative of a tropane alkaloid product that makes use of the cell is also described.
Claims19
An engineered non-plant cell that produces a precursor of a tropane alkaloid product, a tropane alkaloid product, or a derivative of a tropane alkaloid product, wherein the engineered non-plant cell comprises a heterologous coding sequences encoding hyoscyamine dehydrogenase (HDH) within a pathway for producing the precursor of a tropane alkaloid product, the tropane alkaloid product, or the derivative of a tropane alkaloid product.
Dependencies are inferred from the claim text.