Streamlined methods for making liquid media

A method for preparing a liquid medium comprising:

• grouping amino acids in a formulation according to their pH, solubility, and concentration;
• wherein the amino acids are acidic, basic, and neutral amino acids;
• converting the amino acids into their free base form or salt form to target a particular pH according to other media components in the formulation;
• separating the converted amino acids into acidic, basic, and neutral sub-groups;
• matching the grouped amino acids to determine an order of addition based on their acidic, basic, and neutral sub-groups, such that when adding the converted amino acid based on the grouping of the amino acids to a formulation tank in the order of addition determined reduces adding additional acids or bases to achieve a particular pH for the liquid medium;
• wherein the additional acids or bases comprise at least one metal contaminant;
• adding water to the formulation tank;
• and
• adding the converted amino acids to the formulation tank in the order of addition determined based on the matching, wherein the order of addition reduces a level of the at least one metal contaminant in the formulation tank as the other media components are being added to prepare the liquid medium at the particular pH.