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US 12,479,920 B2Granted
PD1 and VEGFR2 dual-binding agents
AssigneeOttimo Pharma Limited
InventorWilliam James Jonathan Finlay
Life of this patent
Estimating the term…
Abstract
Provided herein are antibody molecules that bind specifically to Programmed cell death 1 (PD1) and Vascular endothelial growth factor receptor 2 (VEGFR2), related nucleic acid molecules, vectors and host cells. Also provided herein are medical uses of such antibody molecules.
Claims30
An antibody molecule that specifically binds to PD1 and VEGFR2, wherein the antibody molecule comprises:
- (a) a heavy chain variable (VH) region comprising
- a HCDR1 having an amino acid sequence of SEQ ID NO:
- 1,
- a HCDR2 having an amino sequence of SEQ ID NO:
- 42, and
- a HCDR3 having an amino acid sequence of SEQ ID NO:
- 3, and
- (b) a light chain variable (VL) region comprising
- a LCDR1 having an amino acid sequence of SEQ ID NO:
- 39,
- a LCDR2 having an amino sequence of SEQ ID NO:
- 40, and
- a LCDR3 having an amino acid sequence of SEQ ID NO:
- 11.
11 more elements
An antibody molecule that specifically binds to PD1 and VEGFR2, wherein the antibody molecule comprises:
- (a) a heavy chain comprising a VH region having an amino acid sequence of SEQ ID NO:
- 49, and an IgG1 immunoglobulin constant region having an amino acid sequence of SEQ ID NO:
- 28, and
- (b) a light chain comprising a VL region having an amino acid sequence of SEQ ID NO:
- 45.
2 more elements
An antibody molecule that specifically binds to PD1 and VEGFR2, wherein the antibody molecule comprises:
- (a) a VH region comprising
- a HCDR1 having an amino acid sequence of SEQ ID NO:
- 1,
- a HCDR2 having an amino sequence of SEQ ID NO:
- 42, and
- a HCDR3 having an amino acid sequence of SEQ ID NO:
- 3, and
- (b) a VL region comprising
- a LCDR1 having an amino acid sequence of SEQ ID NO:
- 39,
- a LCDR2 having an amino sequence of SEQ ID NO:
- 5, SEQ ID NO:
- 41, or SEQ ID NO:
- 43, and
- a LCDR3 having an amino acid sequence of SEQ ID NO:
- 11.
13 more elements
Dependencies are inferred from the claim text.