T cell receptors recognizing R175H or Y220C mutation in P53
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsDrew C. Deniger, Parisa Malekzadeh, Steven A. Rosenberg
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Abstract
Disclosed are isolated or purified T cell receptors (TCRs) having antigenic specificity for human p53R175H or human p53Y220C. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
Claims35
An isolated or purified T cell receptor (TCR) having antigenic specificity for a human p53Y220C amino acid sequence, wherein the TCR comprises the amino acid sequences of all of SEQ ID NOs:
- 80-85.
An isolated or purified protein comprising:
- a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOS:
- 80-82 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs:
- 83-85.
An isolated or purified nucleic acid comprising, from 5′ to 3′, a first nucleotide sequence and a second nucleotide sequence, wherein the first and second nucleotide sequence, respectively, encode the amino sequences of SEQ ID NOs:
- 86 and 87;
- 87 and 86;
- 156 and 157;
- 157 and 156;
- 199 and 87;
- 87 and 199;
- 86 and 219;
- or 219 and 86.
Dependencies are inferred from the claim text.