Immunogenic protein against gonococcal infection
AssigneeGriffith University
InventorsKate Seib, Evgeny Semchenko
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Abstract
This invention relates, inter alia, to an immunogenic fragment of a Neisserial Heparin Binding Antigen (NHBA) protein of Neisseria gonorrhoeae (SEQ ID NO: 1) for the prevention and treatment of Neisseria gonorrhoeae or gonococcal- or meningococcal-associated diseases and conditions. In some embodiments, the immunogenic fragment corresponds to a C-terminal fragment of the protein (SEQ ID NO: 2).
Claims8
An immunogenic fragment of an isolated Neisserial Heparin Binding Antigen (NHBA) protein of Neisseria gonorrhoeae, wherein the immunogenic fragment is between about 165 amino acids to about 200 amino acids in length and wherein the immunogenic fragment comprises, is contained in, consists of or consists essentially of an amino acid sequence set forth in SEQ ID NO:
- 2 or a variant thereof, wherein the variant shares at least 97% sequence identity with SEQ ID NO:
- 2.
An isolated protein comprising one or a plurality of an immunogenic fragments of an isolated Neisserial Heparin Binding Antigen (NHBA) protein of Neisseria gonorrhoeae, wherein the immunogenic fragments are between about 165 amino acids to about 200 amino acids in length and wherein the immunogenic fragments comprises, is contained in, consists of or consists essentially of an amino acid sequence set forth in SEQ ID NO:
- 2 or a variant thereof, wherein the variant shares at least 97% sequence identity with SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.