Chimeric antigen receptor constructs and their use in CAR-T cells
AssigneeThe University of North Carolina at Chapel Hill
InventorLishan Su
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Abstract
The present invention is directed to chimeric antigen receptor (CAR) compositions and methods of their use in cancer and anti-viral immunotherapy. In particular, the CAR of the invention comprises a costimulatory signal (CSS) domain comprising herpes virus entry mediator protein (HVEM) or a functional fragment or variant thereof. CARs comprising such a HVEM CSS exhibit enhanced effector function.
Claims17
A nucleic acid molecule encoding a chimeric antigen receptor (CAR) comprising, in order, an antigen binding domain, a herpes virus entry mediatory (HVEM) protein transmembrane domain, a costimulatory signal (CSS) domain comprising a HVEM protein CSS domain consisting of the amino acid sequence of SEQ ID NO:
- 2, and a T-cell receptor domain.
Dependencies are inferred from the claim text.