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US 12,479,887 B2Granted
Inhibitors for protein n-terminal methyltransferase and uses thereof
AssigneePurdue Research Foundation
InventorsRong Huang, Dongxing Chen, Guangping Dong
Life of this patent
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Abstract
The present invention relates to series of peptidomimetic compounds as an inhibitor targeting protein N-terminal methyltransferase pharmacological pathway. Pharmaceutical compositions of those compounds and methods of using them in the treatment of diseases caused by abnormal protein methyltransferase pathway, including cancer, inflammation, neurodegenerative and cardiovascular diseases, are within the scope of this disclosure.
Claims2
A compound selected from the group consisting of:
- wherein the compound exhibits N-terminal methyltransferase 1 (NTMT1) inhibiting activity.
Dependencies are inferred from the claim text.