Compound having Axl and c-Met kinase inhibitory activity, preparation thereof and application thereof

A compound of formula (I) or its stereoisomer, geometric isomer, tautomer, its pharmaceutically acceptable salt, its hydrate or solvate,

• wherein, T is selected from the group consisting of substituted or unsubstituted 5-10 membered aryl;
• the “substituted” means that one or more hydrogen atoms on the group is substituted by a substituent selected from the group consisting of unsubstituted C1-C6 alkyl, unsubstituted C3-C8 cycloalkyl, or halogen;
• U is selected from the group consisting of substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C2-C6 alkynyl;
• the “substituted” means that one or more hydrogen atoms on the group is substituted by a substituent selected from the group consisting of unsubstituted C1-C6 alkoxy;
• Q is selected from N or C—Rc;
• V1, V2, V3 and V4 are the same or different, and are each independently C—Rd;
• Rc is H;
• Rd is selected from the group consisting of H, unsubstituted C1-C6 alkyl, or halogen;
• Z is formula (V):
• wherein R5a is at each occurrence independently selected from the group consisting of H, unsubstituted C1-C6 alkyl, unsubstituted C2-C6 alkenyl, or unsubstituted C2-C6 alkynyl;
• or the compound having formula (I) has formula (VI) or formula (VII):
• wherein R2a, R2b and R2c are at each occurrence independently selected from the group consisting of H, unsubstituted C1-C6 alkyl, unsubstituted C2-C6 alkenyl, unsubstituted C2-C6 alkynyl, unsubstituted-(CH2)t—(C3-C11 cycloalkyl), unsubstituted —(CH2)t-(3-11 membered heterocycloalkyl), and unsubstituted-(CH2)t—OR2d;
• R2d is H;
• W1, W2, W3, and W4 are at each occurrence independently selected from C—R1a;
• each R1a is H;
• each t is independently selected from 0, 1, 2, 3, or 4;
• or the compound having formula (I) has formula (XI) or formula (XII):
• wherein X1 is N or O;
• R4a is selected from the group consisting of H, halogen, and unsubstituted C1-C6 alkyl;
• Rg, Rh, Ri, Rj are at each occurrence independently H;
• for compound (XI), dotted line is a double bond;
• for compound (XII), dotted line is a single bond;
• M is C—H or N;
• Rk is at each occurrence independently selected from the group consisting of H, unsubstituted C1-C6 alkyl, unsubstituted C2-C6 alkenyl, or unsubstituted C2-C6 alkynyl.