HMG-CoA reductase degradation inducing compound

A compound represented by Formula I, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

• ULM Linker PTM [Formula 1]
• in the Formula I above,
• ULM is a CRBN E3 ubiquitin ligase binding moiety represented by Formula A-2;
• wherein:
• X2 is —CH2—, —CO— or —N═N—;
• X3 is hydrogen;
• and
• indicates a covalent bond that links ULM into the Linker;
• PTM is a HMG-CoA reductase binding moiety represented by Formula II:
• in Formula II above,
• R1 is
• RL is a single bond or C1-6 alkylene that is optionally substituted by 1-4 substituents selected from —CH3, —CN, —NH2, —OH, or halogen;
• R2 is selected from hydrogen, halogen, —OH, —O(C1-6 alkyl), —O(C3-8 cycloalkyl), —OCO(C1-C6 alkyl),
• optionally substituted by one or more straight- or branched-C1-4 alkyl, 5- to 6-membered heterocyclyl containing one or two N ring atoms, phenyl, 6-membered heteroaryl containing one or two N ring atoms, NH3, OH, or CF3;
• R3 and R4 are each independently —OH or —O(C1-3 alkyl);
• or R3 and R4 together form —O—;
• R3 and R4 are each independently hydrogen, halogen, OH, C1-4 alkyl, C1-4 alkenyl, O(C1-4 alkyl), CF3, NH3, NO2, or CN;
• R7 is hydrogen or C1-3 alkyl;
• is a single bond or a double bond;
• indicates a covalent bond that links PTM into the Linker};
• and
• the Linker is a chemical group that links ULM and PTM, wherein the Linker is represented by Formula L:
• wherein:
• and are each independently a bond;
• LULM is covalently bonded to a ULM moiety through that is linked thereto,
• LPTM is covalently bonded to a PTM moiety through that is linked thereto,
• LULM is
• LU1 is selected from —CH2—, —CH2CH2—, —CC—, —NH—, —NHCO—, or —O—;
• LU2 is selected from a single bond, —CH2—, —NH—, —O—, —CO—, and —CONH—;
• is null, C1-3 alkyl, or 4- to 6-membered heterocycloalkyl containing one or two N ring atoms;
• LPTM is
• LP1 is selected from a single bond, —NH—, —NCH3, or —CH2NH—;
• LP2 is selected from a single bond or —COCH2—;
• is null or 4- to 6-membered heterocycloalkyl containing one or two N ring atoms;
• is null or a ring selected from 4- to 6-membered heterocycloalkyl containing one or two N ring atoms, phenyl, or 5- to 6-membered heteroaryl containing one or two N ring atoms;
• LINT1 and LINT2 are each independently selected from —CH2—, —NH—, —CH2CH2O—, or —OCH2CH2—;
• and
• q and r are each independently an integer from 1 to 8.