Reversible DPP1 inhibitors and uses thereof

A compound of formula (I)

• or a pharmaceutically acceptable salt or deuterated form thereof,
• wherein:
• R0 is
• X1 and X2 are independently O, S, NH, N(C1-6 alkyl), or CR12R13, wherein at least one of X1 and X2 are not CR12R13;
• L is aryl, heterocyclyl, heteroaryl, or
• wherein L is independently substituted by 0-4 R10 and wherein ring B is a carbocycle, or a heterocycle;
• R1 is
• R2 is H, F, Cl, Br, OSO2C1-6 alkyl, or C1-6 alkyl;
• R3 is H, F, Cl, Br, CN, C1-6haloalkyl, SO2C1-6 alkyl, CONH2, or SO2NR4R5, wherein R4 and R5 together with the nitrogen atom to which they are attached form a heterocyclyl;
• X is O, S, CHF, or CF2;
• Y is O, S, or CH2;
• Q is CH or N;
• R6 is C1-6 alkyl optionally substituted by 1, 2 or 3 F, or optionally substituted by OH, OC1-6 alkyl, N(C1-6 alkyl)2, N(C1-6 alkyl)(C1-6alkylene-O—C1-6 alkyl), cycloalkyl, or heterocyclyl;
• R7 is H, F, Cl, Br, or C1-6 alkyl;
• each R8 and R12 are independently H, OH, halogen, NH2, COOH, C1-6 alkyl, C1-6 alkyl-OH, C2-6alkenyl, C1-6alkoxy, O-cycloalkyl, cycloalkyl, C1-6alkylene-carbocyclyl, C1-6alkylene-heteroaryl, halogenated C1-6 alkyl, halogenated C1-6alkoxy, heteroaryl, or carbocyclyl;
• each R13 is independently H, F, Cl, Br, I, or C1-C6 alkyl;
• each R10 is independently oxo, halogen, C1-6 alkyl, C1-6alkoxy, S-C1-6 alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, cyano, hydroxy, NH2, —NH—C1-6 alkyl, N(C1-6 alkyl)2, COOH, COC1-6 alkyl, COOC1-6 alkyl, CON1-6 alkyl, CON(C1-6 alkyl)2, NHCOC1-6 alkyl, or heterocycle;
• wherein each alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, and heterocycle are independently optionally substituted with 1-3 substituents selected from halogen, cyano, hydroxy, NH2, and COOH;
• W, X4, and Y2 are each independently CH or N, provided that a maximum of one of W, X4, and Y2 can be N;
• D-E is N(H)—C(O), N(C1-6 alkyl)-C(O), CH2CH2, C(O)—O, or CH2—O;
• R11 is H, C1-6 alkyl, alkylene-O-alkyl, or heterocyclyl;
• and
• i and j are each independently 1, 2 or 3, provided that the sum of i+j is 2, 3, or 4.