Bioconjugation reagent and methods
AssigneeUniversiteit Gent
InventorsAnnemieke Madder, Ewout De Geyter, Eirini Antonatou, Sabina Smolen, Dimitris Kalaitzakis, Georgios Vassilikogiannakis
Life of this patent
Estimating the term…
Abstract
The present invention in general relates to the field of bioconjugation. More in particular, the invention relates to novel bioconjugation reactants based on an α,β unsaturated γ-hydroxylactam structure, amongst others allowing a higher degree of functionalization compared to classical bioconjugation reactants such as maleimide. The present invention also provides methods of preparing the novel bioconjugation reactants, as well as uses thereof in human and/or veterinary medicine; and conjugation processes.
Claims12
A compound according to formula (IV):
- where:
- L1 is a C1-C20 alkyl;
- L2 is absent;
- R1 represents any carbon-containing moiety selected from the group consisting of small molecules, carboxylic acids, esters, ethers, amides, maleimides, alkynes, azides, tetrazines, dienes, small heterocycles, alkoxyamines, aromatics, polyaromatics, and saturated or unsaturated alkyl chains;
- R2 represents a saturated or unsaturated C1-C20 alkyl;
- R4 is selected from the group consisting of small molecules, biomolecules, and macromolecules;
- and
- R7 is —OH.
Dependencies are inferred from the claim text.