Acetophenone oxime compound and application thereof

A compound represented by formula (II) or a pharmaceutically acceptable salt thereof,

• wherein
• the structural moiety
• is selected from
• m is selected from 1 and 2;
• T1 is selected from CR5 and N;
• R1 and R2 are each independently selected from H, -L1-NRa-L2-COOH, -L1-NRa-L2-cyclopropyl, -azetidinyl-COOH and -piperidyl-COOH, wherein the -L1-NRa-L2-COOH, -L1-NRa-L2-cyclopropyl, -azetidinyl-COOH and -piperidyl-COOH are optionally substituted with 1, 2 or 3 Rb;
• L1 is selected from a single bond or CH2;
• L2 is C1-3 alkyl;
• R3 and R5 are each independently selected from H, F, Cl, Br, CN and C1-3 alkyl, wherein the C1-3 alkyl is optionally substituted with 1, 2 or 3 Rc;
• R4 is selected from —O—C1-6 alkyl, —O—C1-3 alkyl-cyclopropyl, —O—C3-6 cycloalkyl and C3-6 cycloalkyl, wherein the C1-3 alkyl, C1-6 alkyl and C3-6 cycloalkyl are optionally substituted with 1, 2 or 3 Rd;
• R6 is selected from H and —NRa—C1-3 alkyl-COOH, wherein the —NRa—C1-3 alkyl-COOH is optionally substituted with 1, 2 or 3 Re;
• Ra is selected from H and CH3;
• Rb is selected from H, F, Cl, Br, I and COOH;
• Rc and Rd are each independently selected from H, F, Cl, Br and I;
• Re is each independently selected from H, F, Cl, Br and I.