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US 12,478,966 B2Granted
System and method for immune activity determination
AssigneeCytoVale Inc.
InventorsHenry Tat Kwong Tse, Ajay M. Shah, Lionel Guillou, Roya Sheybani, Christopher Dahlberg, Anne E. Jensen
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Abstract
A system and method for determining a trajectory parameter of particles, comprising receiving a plurality of particles at a microfluidic channel, applying a force to each particle of the microfluidic channel, acquiring a dataset of each particle, measuring a trajectory of the particle, and determining a trajectory parameter of the particles.
Claims19
A system for determining a sepsis condition of a patient, comprising:
- a microfluidic channel comprising:
- an inlet;
- a focusing region configured to align cells from a patient sample;
- a first branch and a second branch, wherein a plurality of the cells from the patient are directed through either the first branch or the second branch;
- and
- a deformation region wherein the first branch and the second branch intersect within the deformation region, wherein cells from the patient sample undergoes a deformation within the deformation region;
- an image acquisition system comprising a field of view that overlaps the deformation region;
- and
- a processor configured to:
- determine a trajectory of each cell passing through the deformation region, wherein the trajectory comprises a series of discrete positions of the cell as the cell passes through the deformation region, and wherein the trajectory comprises an oscillation of a centroid of the cell;
- and
- determine one or more trajectory parameters associated with each cell of the patient subject, wherein the trajectory parameters comprise at least one of a difference, sum, amplitude, maximum, and average value of one or more positions of the trajectory;
- and
- determine the sepsis condition of the patient based on the trajectory parameters.
11 more elements
Dependencies are inferred from the claim text.