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US 12,478,684 B2Granted
Oligonucleotide-polymer miktoarm conjugates and methods of use
AssigneeNortheastern University
InventorKe Zhang
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Abstract
Monodisperse structures with precise numbers of polymer arms and oligonucleotide chains conjugated to a backbone are disclosed. The structures, referred to miktoarm conjugates, are resistant to nuclease degradation and are capable of regulating gene expression in the absence of a co-carrier.
Claims18
A miktoarm conjugate, comprising a backbone core;
- a predetermined number of from 5 to 50 polymer arms covalently linked to the backbone core;
- and a predetermined number of from 1 to 10 oligonucleotides covalently linked to the backbone core,
- wherein each of the oligonucleotides is sufficiently complementary to a target polynucleotide to hybridize to the target polynucleotide or can bind to a non-nucleic acid target under predetermined conditions;
- and wherein:
- a) the backbone core is linear, and wherein the miktoarm conjugate does not comprise a triazole;
- or
- b) the backbone core is non-linear.
4 more elements
Dependencies are inferred from the claim text.