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US 12,478,676 B2Granted
Method of imaging
AssigneeExact Therapeutics AS
InventorsAndrew John Healey, Per Christian Sontum, Svein Kvale
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Abstract
The present disclosure relates to a method of imaging, involving administration of a bi-phasic formulation followed by application of high frequency sound waves to identify a region of interest. Following identification, a phase shift of the bi-phasic formulation may be activated by a second administration of high frequency sound waves such that gaseous components of the bi-phasic formulation are enlarged and localised at the region of interest.
Claims9
A method of high frequency sound wave imaging control of agent delivery to a subject, the method comprising:
- administering a two-component, bi-phasic formulation and a separate therapeutic agent to the subject, wherein the therapeutic agent is selected from the group consisting of genes, chemotherapeutics and immunotherapeutics;
- imaging a plurality of gaseous components of the bi-phasic formulation to identify a region of interest within said subject;
- activating a phase shift of a vaporous component of the bi-phasic formulation by a first high frequency sound wave application of the region of interest, such that individual gaseous components are enlarged by the vaporous component to give enlarged individual gaseous components localised at the region of interest;
- applying a second high frequency sound wave to the region of interest to oscillate the enlarged gaseous components;
- and
- analysing the acoustic signature produced by the enlarged gaseous components to quantify the amount of therapeutic agent delivered,
- wherein the therapeutic agent is delivered separately from the bi-phasic formulation, and wherein the first high frequency is different from the second high frequency and wherein the second high frequency sound wave comprises a frequency in the range of 0.05 to 1 MHz.
4 more elements
Dependencies are inferred from the claim text.