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US 12,478,671 B2Granted
Sterols as novel immunomodulatory agents and their use as vaccine adjuvants
AssigneeOhio State Innovation Foundation
InventorsAbhay R. Satoskar, James R. Fuchs, Alan Douglas Kinghorn, Li Pan, Eric Bachelder, Narasimham L. Parinandi
Life of this patent
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Abstract
Disclosed herein are methods of using immunomodulatory sterols as vaccine adjuvants. Accordingly, certain embodiments relates to pharmaceutical compositions containing at least one antigen and at least one immunomodulatory sterol; and, methods of inducing an immunomodulatory response in a patient by administering an immunomodulatory-effective amount of at least one immunomodulatory sterol.
Claims16
A pharmaceutical composition comprising an immunomodulatory sterol having the following structure:
- wherein
- R1 is selected from C1-C12 alkyl and C1-C12 alkenyl, and an antigen, wherein the antigen comprises killed, inactivated, attenuated, or modified live bacteria, viruses, or parasites,
- wherein the immunomodulatory sterol is present in an amount from 0.1 to 100 μg.
Dependencies are inferred from the claim text.