Herpes zoster mRNA vaccine, preparation method therefor, and use thereof
AssigneeHangzhou Tianlong Pharmaceutical Co., Ltd.
InventorsGengshen Song, Kai Dong, Zhongbin Chen, Yanfen Li, Yuting Zhou, Jing Li, Xin Chai, Zhongcai Gao, Jinyu Zhang, Huanyu Wang
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Abstract
The present disclosure belongs to the technical field of mRNA vaccines, and specifically relates to a herpes zoster mRNA vaccine, a preparation method therefor, and a use thereof. The herpes zoster mRNA vaccine provided by the present disclosure comprises an RNA encoding a varicella-zoster virus gE glycoprotein or a variant thereof. The vaccine can prevent herpes zoster infection and its complications.
Claims49
An immunogenic composition, comprising a ribonucleic acid (RNA) of a varicella-zoster virus (VZV) encoding a variant of the wild-type VZV gE glycoprotein;
- wherein the sequence of the wild-type VZV gE glycoprotein is SEQ ID NO:
- 3;
- wherein the variant of the VZV gE glycoprotein is the variant selected from:
- YK-VZV-020, YK-VZV-030, YK-VZV-031, YK-VZV-009, YK-VZV-010, YK-VZV-011, YK-VZV-012, YK-VZV-013 and YK-VZV-014,
- Sequence
- Sequence
- Name
- truncation
- Site mutation
- deletion
- YK-VZV-020
- gE (1 to 573)
- Y569K
- No sequence
- deletion
- YK-VZV-030
- gE (1 to 587)
- A568D;
- Y569K;
- R570E;
- No sequence
- V571K;
- Y582A
- deletion
- YK-VZV-031
- gE (1 to 587)
- A568D;
- Y569K;
- R570E;
- No sequence
- V571K;
- Y582G
- deletion
- YK-VZV-009
- No sequence
- Y569K;
- Y582A
- No sequence
- truncation
- deletion
- YK-VZV-010
- No sequence
- Y569K;
- Y582A;
- S593A;
- No sequence
- truncation
- S595A;
- T596A;
- T598A
- deletion
- YK-VZV-011
- No sequence
- A568D;
- Y569K;
- R570E;
- No sequence
- truncation
- V571K
- deletion
- YK-VZV-012
- No sequence
- A568D;
- Y569K;
- R570E;
- No sequence
- truncation
- V571K;
- S593A;
- S595A;
- deletion
- T596A;
- T598A
- YK-VZV-013
- No sequence
- A568D;
- Y569K;
- R570E;
- No sequence
- truncation
- V571K;
- Y582A
- deletion
- YK-VZV-014
- No sequence
- A568D;
- Y569K;
- R570E;
- No sequence
- truncation
- V571K;
- Y582A;
- S593A;
- deletion
- S595A;
- T596A;
- T598A.
Dependencies are inferred from the claim text.