Vaccines for recurrent respiratory papillomatosis and methods of using the same
AssigneeInovio Pharmaceuticals, Inc.
InventorsStephanie Ramos, Jewell Walters, Jian Yan, Anna Slager, Charles Reed, Kate Broderick
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Abstract
Provided herein are nucleic acid molecules encoding an HPV antigen. Also provided are vaccines against human papillomavirus (HPV) comprising the nucleic acids, methods of inducing immune responses, and methods for prophylactically and/or therapeutically immunizing individuals against recurrent respiratory papillomatosis (RRP). Pharmaceutical compositions, recombinant vaccines comprising DNA plasmid and live attenuated vaccines are disclosed as well as methods of inducing an immune response to treat or prevent RRP are disclosed.
Claims36
A nucleic acid molecule comprising a nucleic acid sequence encoding a human papillomavirus 11 (HPV11) E6 antigen, a nucleic acid sequence encoding a HPV11 E7 antigen, a nucleic acid sequence encoding a human papillomavirus 6 (HPV6) E6 antigen, and a nucleic acid sequence encoding a HPV6 E7 antigen, wherein:
- the HPV11 E6 antigen comprises residues 1-149 of SEQ ID NO:
- 1 or an amino acid sequence having at least 99% identity to residues 1-149 of SEQ ID NO:
- 1,
- the HPV11 E7 antigen comprises residues 179-275 of SEQ ID NO:
- 1 or an amino acid sequence having at least 99% identity to residues 179-275 of SEQ ID NO:
- 1,
- the HPV6 E6 antigen comprises residues 305-453 of SEQ ID NO:
- 1 or an amino acid sequence having at least 99% identity to residues 305-453 of SEQ ID NO:
- 1, and
- the HPV6 E7 antigen comprises residues 483-579 of SEQ ID NO:
- 1 or an amino acid sequence having at least 99% identity to residues 483-579 of SEQ ID NO:
- 1;
- and
- wherein:
- the nucleic acid sequence encoding a HPV11 E6 antigen comprises nucleotides 1-447 of SEQ ID NO:
- 2 or a nucleic acid sequence having at least 99% identity to nucleotides 1-447 of SEQ ID NO:
- 2,
- the nucleic acid sequence encoding a HPV11 E7 antigen comprises nucleotides 535-825 of SEQ ID NO:
- 2 or a nucleic acid sequence having at least 99% identity to nucleotides 535-825 of SEQ ID NO:
- 2,
- the nucleic acid sequence encoding a HPV6 E6 antigen comprises nucleotides 913-1359 of SEQ ID NO:
- 2 or a nucleic acid sequence having at least 99% identity to nucleotides 913-1359 of SEQ ID NO:
- 2,
- the nucleic acid sequence encoding a HPV6 E7 antigen comprises nucleotides 1447-1737 of SEQ ID NO:
- 2 or a nucleic acid sequence having at least 99% identity to nucleotides 1447-1737 of SEQ ID NO:
- 2, or
- any combination thereof.
Dependencies are inferred from the claim text.