Methods of purifying an allergen extract
AssigneeLETI Pharma, S.L.
InventorsMarta Román-Escutia, María Morales, María Teresa Gallego, Jerónimo Carnés Sánchez
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Abstract
The invention relates to processes for producing semi-purified and purified allergen extracts and pharmaceutical compositions and vaccines for use in the diagnosis and treatment of allergy. In one aspect of the invention, a process for producing a depigmented allergen extract is provided, the process comprising: a) basifying a native allergen extract; and b) removing molecules having a molecular size of less than 3.5 kDa; and c) adjusting the pH to neutrality; thereby to produce a depigmented allergen extract.
Claims11
A process for producing a depigmented allergen extract, the process comprising:
- a) basifying a native allergen extract to pH 7 to 11 for 1 minute to 24 hours, wherein the native allergen extract is derived from a source material selected from the group consisting of Phleum pratense, Olea europaea, and Dermatophagoides pteronyssinus;
- then
- b) subjecting the extract to a first molecular fraction removal step to remove molecules having a molecular size of less than 3.5 kDa;
- and
- c) adjusting the pH to neutrality to produce a depigmented allergen extract.
Dependencies are inferred from the claim text.