Micronized compositions for wound healing prepared from intact human amnion-chorion tissue having an intact intermediate spongy layer positioned there between
AssigneeBiostem Technologies, Inc.
InventorsJason V. Matuszewski, Wendy W. Weston
Life of this patent
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Abstract
A sterile micronized composition prepared from intact human placental tissue that is configured for wound healing. The sterile micronized composition includes micronized human amnion; micronized human chorion; and micronized human intermediate spongy layer. In certain aspects, the composition is prepared from intact placental tissue comprising a human amnion layer, human chorion layer, and an intact human intermediate spongy layer positioned between the human amnion layer and human chorion layer such that immediately before micronization the human amnion layer and the human chorion layer are not separated from one another.
Claims21
A sterile micronized composition prepared from intact human placental tissue, the sterile micronized composition comprising:
- (a) micronized human amnion;
- (b) micronized human chorion;
- and
- (c) micronized human intermediate spongy layer;
- wherein the composition is prepared from intact placental tissue in cross-section comprising a human amnion layer, human chorion layer, and an intact human intermediate spongy layer positioned between and connecting the human amnion layer to the human chorion layer such that immediately before micronization the human amnion layer and the human chorion layer are not separated from one another;
- wherein the composition is prepared without the use of exogenous enzymes;
- and
- wherein the composition comprises HA ranging from 1.0×107 to 1.0×108 pg/cm2;
- and at least two of the following:
- (a) IL-1ra ranging from 1.0×102 to 5.0×104 pg/cm2;
- (b) HGF ranging from 5.0×102 to 1.0×104 pg/cm2;
- (c) VEGFR1 ranging from 5.0×102 to 5.0×103 pg/cm2;
- (d) GAGs;
- and
- (e) Collagen.
Dependencies are inferred from the claim text.