Composition for treating intervertebral disc
AssigneesNational University Corporation Hokkaido University, Mochida Pharmaceutical Co., Ltd.
InventorsHideki Sudo, Takeru Tsujimoto, Norimasa Iwasaki, Satoshi Shimizu, Mitsuko Isaji
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Abstract
The present invention provides a composition for filling the nucleus pulposus of an intervertebral disc, the composition containing a low endotoxin monovalent metal salt of alginic acid. The composition is applied to a nucleus pulposus site of a subject, is used so as to be cured partially after application, and has fluidity when applied to the nucleus pulposus site. Accordingly, a composition for filling nucleus pulposus is provided, the composition being capable of promoting the regeneration of the nucleus pulposus of an intervertebral disc.
Claims25
A method of treating or reducing a degeneration and/or an injury of an intervertebral disc, wherein the degeneration and/or the injury comprises a defective site in a nucleus pulposus of the intervertebral disc, the method comprises applying to the defective site of a nucleus pulposus of an intervertebral disc in a subject in need thereof via a composition-filling inlet on the surface of the intervertebral disc a composition in a sol state to fill the defective site, the composition comprising a low endotoxin monovalent metal salt of alginic acid, and allowing a solid gel to form from a first portion of the composition after the applying by bringing a crosslinking agent into contact with the composition-filling inlet on the surface of the intervertebral disc, such that a second portion, which is other than the first portion, of the composition remains in the sol state, wherein the first portion corresponds to the surface of the composition located at the surface inlet and the second portion corresponds to the remainder of the composition other than the surface.
A method of treating or reducing a degeneration and/or an injury of an intervertebral disc, wherein the degeneration and/or the injury comprises a defective site in a nucleus pulposus of the intervertebral disc, the method comprises applying to the defective site of a nucleus pulposus of an intervertebral disc of a subject in need thereof via a composition-filling inlet on the surface of the intervertebral disc a composition comprising a low endotoxin monovalent metal salt of alginic acid to fill the defective site and curing the composition after the applying by bringing a crosslinking agent into contact with at least a part of the surface of the composition in the composition-filling inlet on the surface of the intervertebral disc, wherein the composition has fluidity when applied to the defective site, and wherein the composition is gelled only on the surface thereof.
Dependencies are inferred from the claim text.