PI3K inhibitors and uses thereof

A compound of Formula (II):

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is hydrogen, halogen, —CN, —N3, —NO2, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, —ORO, —N(RN)2, or —SRS;
• each instance of R3 is independently hydrogen, halogen, —CN, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, —ORO, —N(RN)2, or —SRS;
• each instance of R4 is independently hydrogen, halogen, —CN, —N3, —NO2, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, —ORO, —N(RN)2, or —SRS;
• each instance of R5 is independently hydrogen, halogen, optionally substituted alkyl, —CN, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, —ORO, —N(RN)2, or —SRS;
• or two R5 are joined together with the intervening atoms to form optionally substituted carbocyclyl or optionally substituted heterocyclyl;
• RN1 is hydrogen, optionally substituted alkyl, optionally substituted acyl, or a nitrogen protecting group;
• each instance of RN2 is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, or a nitrogen protecting group;
• or optionally two RN2 are joined together with the intervening atoms to form optionally substituted heterocyclyl or optionally substituted heteroaryl;
• each instance of RN is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, or a nitrogen protecting group;
• or optionally two RN are joined together with the intervening atoms to form optionally substituted heterocyclyl or optionally substituted heteroaryl;
• each instance of RO is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, or an oxygen protecting group;
• each instance of RS is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, or a sulfur protecting group;
• n is 0, 1, 2, 3, 4, or 5;
• m is 0, 1, 2, or 3;
• p is 0, 1, or 2;
• R6 is haloalkyl, —C(═O)ORO2, —(C(R5)2)pC(═O)ORO2, —ORO, —N(RN)2, or —SRS;
• and
• R7 and R8 are each independently hydrogen, halogen, —CN, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, —ORO, —N(RN)2, or —SRS;
• each instance of RO is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, or an oxygen protecting group;
• provided that when R6 is —CF3, then R7 is hydrogen or optionally substituted acyl, and at least one of R7 or R8 is not hydrogen;
• and
• provided that when R6 is —CF3, then R8 and R7 are independently hydrogen or optionally substituted acyl, and at least one of R7 or R8 is not hydrogen.