Antimicrobial solutions and methods of using the same in the treatment or prevention of infections
OwnerGudmundur Fertram Sigurjonsson, Dora Hlin Gisladottir +1inventors
InventorsGudmundur Fertram Sigurjonsson, Dora Hlin Gisladottir, Jon Magnus Kristjansson
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Abstract
Antimicrobial compositions include a therapeutically effective amount of neem oil, extract of the plant Hypericum spp., polyunsaturated fatty acids (PUFAs), carrageenans, and/or chlorhexidine; and (optionally) in combination with one or more pharmaceutically acceptable carriers, additives, and/or diluents. The antimicrobial compositions are effective in treating or preventing upper respiratory tract infections, preferably upper respiratory tract infections caused by human Coronaviruses and are included within methods of treating or preventing infection of the upper respiratory tract of humans by a microbial pathogen.
Claims34
An antimicrobial solution, comprising:
- an extract of the plant Hypericum spp. in a volumetric proportion of 2.5% to 60% (v/v) of a total volume of the antimicrobial solution;
- Neem oil;
- one or more pharmaceutically acceptable carriers, additives, and/or diluents that configure the antimicrobial solution to form a barrier film in a nasal mucosa, oral mucosa, and/or oropharyngeal mucosa of a subject;
- and
- polyunsaturated fatty acids (PUFAs).
An antimicrobial solution, comprising:
- an extract of the plant Hypericum spp. in a volumetric proportion of 2.5% to 60% (v/v) of a total volume of the antimicrobial solution;
- Neem oil;
- one or more pharmaceutically acceptable carriers, additives, and/or diluents that configure the antimicrobial solution to form a barrier film in a nasal mucosa, oral mucosa, and/or oropharyngeal mucosa of a subject;
- and
- carrageenan.
An antimicrobial solution, comprising:
- an extract of the plant Hypericum spp. in a volumetric proportion of 2.5% to 60% (v/v) of a total volume of the antimicrobial solution;
- Neem oil;
- and
- one or more pharmaceutically acceptable carriers, additives, and/or diluents that configure the antimicrobial solution to form a barrier film in a nasal mucosa, oral mucosa, and/or oropharyngeal mucosa of a subject,
- wherein the pharmaceutically acceptable carrier comprises glycerol.
A method of treatment or prophylaxis, comprising:
- providing an antimicrobial solution that includes
- an extract of the plant Hypericum spp. in a volumetric proportion of 2.5% to 60% (v/v) of a total volume of the antimicrobial solution,
- Neem oil,
- one or more pharmaceutically acceptable carriers, additives, and/or diluents that configure the antimicrobial solution to form a barrier film in a nasal mucosa, oral mucosa, and/or oropharyngeal mucosa of a subject, and
- polyunsaturated fatty acids (PUFAs);
- and
- administering the antimicrobial solution to a mouth and/or nose of a subject.
An antimicrobial solution, comprising:
- an extract of the plant Hypericum spp. in a volumetric proportion of 2.5% to 60% (v/v) of a total volume of the antimicrobial solution;
- Neem oil;
- and
- one or more pharmaceutically acceptable carriers, additives, and/or diluents that configure the antimicrobial solution to form a barrier film in a nasal mucosa, oral mucosa, and/or oropharyngeal mucosa of a subject;
- wherein the one or more pharmaceutically acceptable additives includes a flavor-enhancing additive, and
- wherein the flavor-enhancing additive includes menthol.
Dependencies are inferred from the claim text.