Enzyme based compositions and methods for removing dental calculi
AssigneePontis Biologics, Inc.
InventorDennis C. Mynarcik
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Abstract
Disclosed are compositions and formulations comprising enzymes or other biocatalyst that cleave surface-accessible DNA polymers and/or glycoprotein carbohydrate chains at galactose residues in dental calculus, and optionally further include one or more proteolytic enzymes, thereby destroying the structural integrity of the calculus, and allowing it to be readily removed without requiring special treatment by a trained dental professional. Also disclosed are methods for removing dental calculus using the disclosed compositions and formulations.
Claims21
A dental composition comprising:
- a. a DNase in an amount in Kunitz units/mL of about 50,000 to about 250,000;
- b. chymotrypsin or a functional variant or derivative thereof present in functional units in an amount of about 100 to about 5,000 units/mL;
- and
- c. an orally acceptable additive, carrier or excipient or any combination thereof.
A method for reducing or removing calculus dentalis in a subject in need thereof, the method comprising contacting a tooth surface with an effective amount of a composition comprising:
- a. DNAse I or a functional variant or derivatives thereof in an amount in Kunitz units/mL of about 50,000 to about 250,000, and
- b. chymotrypsin or a functional variant or derivative thereof present in functional units in an amount of about 100 to about 5,000 units/mL;
- wherein the calculus dentalis is reduced by about 15% to 40% within about 2-4 weeks.
Dependencies are inferred from the claim text.