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US 12,476,100 B2Granted
Ionization device, mass spectrometry system, and ionization method
AssigneesBiochromato, Inc., University of Yamanashi
InventorsKazumasa Kinoshita, Takao Nishiguchi, Tomoaki Endo, Kenzo Hiraoka
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Abstract
An ionization device includes an ion formation section configured to ionize an analyte via a corona discharge; and a transfer section configured to transfer the ionized analyte to a mass spectrometry apparatus. The ion formation section and the transfer section are partitioned by one electrode of a pair of electrodes that generate the corona discharge. The one electrode has an opening.
Claims5
An ionization device comprising:
- an ion formation section configured to ionize an analyte via a corona discharge;
- and
- a transfer section configured to transfer an ionized analyte to a mass spectrometry apparatus;
- wherein the ion formation section and the transfer section are partitioned by one electrode of a pair of electrodes that generate the corona discharge, the one electrode having an opening;
- wherein the ion formation section is defined by a space formed between a recess provided in a first end face of a first insulating plate and a second end face of a second insulating plate;
- wherein the first insulating plate and the second insulating plate are fixed together with no gap and without any intervening member between the first insulating plate and the second insulating plate;
- wherein a discharge needle of the other electrode is inserted into a through-hole formed in the second end face;
- and
- wherein the one electrode is disposed in the recess of the first insulating plate to face the discharge needle at a predetermined distance across the ion formation section.
6 more elements
An ionization method for ionizing an analyte, the method comprising:
- generating a corona discharge with a pair of electrodes,
- wherein one of the electrodes has an opening and partitions an ion formation section and a transfer section,
- wherein the ion formation section is defined by a space formed between a recess provided in a first end face of a first insulating plate and a second end face of a second insulating plate;
- wherein the first insulating plate and the second insulating plate are fixed together with no gap and without any intervening member between the first insulating plate and the second insulating plate;
- wherein a discharge needle of the other electrode is inserted into a through-hole formed in the second end face;
- and
- wherein the one electrode is disposed in the recess of the first insulating plate to face the discharge needle at a predetermined distance across the ion formation section;
- supplying an analyte to the vicinity of the corona discharge to ionize the analyte;
- and
- transferring the ionized analyte through the opening of the one electrode to a mass spectrometry apparatus.
7 more elements
Dependencies are inferred from the claim text.