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AssigneeLua Optomekatronik ARGE A.S.
InventorsTayfun Tatar, Onur Samet Yildirim
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An extracellular vesicle characterization and analysis device in terms of their size, phenotype, and cargo content is provided. A method performed with the device to quantify the heterogeneity of extracellular vesicle samples both in terms of size and cargo content and further quantify the purity of extracellular vesicles based on their phenotype and cargo content is further provided. The extracellular vesicle characterization and analysis device includes an atomic force microscope and confocal Raman spectrometer subsystems that will present the phenotypic characterization and cargo analysis of extracellular vesicles, respectively. By processing the topographic images obtained by atomic force microscopy with image processing methods and analyzing them, the dimensional heterogeneity of the extracellular vesicle samples can be quantified and information about their purity can be presented. The confocal Raman spectrometer applies the tip-enhanced Raman spectrum method, performs a heterogeneity quantification and provides data on the purity of the sample.
A method for quantitatively measuring a heterogeneity and a purity of extracellular vesicles from a multiple perspective using a device for a multi-perspective characterization and analysis of the extracellular vesicles, through a system incorporating subsystems for the characterization and analysis of the extracellular vesicles circulating freely in body fluids by multiple methods, comprising:
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