Complexes between CD40 and compounds comprising benzimidazole moieties
AssigneeUcb Biopharma Srl
InventorsJames Philip O′Connell, John Robert Porter, Alastair Lawson, Boris Kroeplien, Stephen Edward Rapecki, Timothy John Norman, Graham John Warrellow
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Abstract
It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. Anew assay for identifying compounds with this mechanism of action is also disclosed.
Claims6
A complex comprising a trimeric protein that is a TNF superfamily member and a compound comprising a benzimidazole moiety that is capable of binding to the trimeric protein that is a TNF superfamily member, whereby the compound-trimer complex binds to a requisite TNF superfamily receptor and modulates the signalling induced by the trimeric protein that is a TNF superfamily member through the receptor,
- wherein the TNF superfamily member is TNFα and the requisite receptor is TNF receptor, or wherein the TNF superfamily member is CD40L and the requisite receptor is CD40.
Dependencies are inferred from the claim text.