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US 12,474,347 B2Granted
Determination of protein information by recoding amino acid polymers into DNA polymers
AssigneeAbrus Bio, Inc.
InventorsMichael Graige, Christopher MacDonald
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to compositions of matter, methods, and systems for analyzing polymeric macromolecules, including polymeric macromolecules such as peptides, polypeptides, and proteins.
Claims18
A chemically-reactive conjugate (CRC) represented by Formula I:
- wherein A comprises a nucleic acid cycle tag indicative of a workflow cycle, B comprises a reactive moiety that covalently binds and cleaves an N-terminal amino acid from a polypeptide, C comprises an immobilizing moiety, LA comprises a bond or linker, LB, comprises a bond or linker, LC comprises a bond or linker,
- comprises a central moiety, and A, B and C are covalently connected to the central moiety through LA, LB, and LC.
A chemically-reactive conjugate (CRC) represented by Formula II:
- A
- -
- L
- AB
- B
- -
- L
- BC
- C
- ,
- (
- Formula
-
- II
- )
- (Formula II), wherein at least one of A, B and C comprises a nucleic acid cycle tag indicative of a workflow cycle, at least one of A, B and C comprises a reactive moiety that covalently binds and cleaves an N-terminal amino acid from a polypeptide, at least one of A, B and C comprises an immobilizing moiety, LAB comprises a bond or linker, LBC comprises a bond or linker, and A, B and C are covalently connected through LAB and LBC.
13 more elements
Dependencies are inferred from the claim text.