Method for determining onset risk of cardiovascular disease in subject, and method for determining vascular calcification in subject
AssigneeSysmex Corporation
InventorsMaria Kiriyama, Eiya Tamada, Elnaz Nakhaei, Mami Onishi
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Abstract
Disclosed is a method of determining onset risk of cardiovascular disease in a subject, the method comprising: capturing, on a solid phase, an extracellular vesicle derived from a blood sample collected from the subject; and measuring alkaline phosphatase activity of the extracellular vesicle, a measured result of the alkaline phosphatase activity being directed for use as an index of the onset risk of cardiovascular disease in the subject.
Claims13
A method of determining onset risk of cardiovascular disease in a subject, the method comprising:
- identifying a subject having or at risk of developing cardiovascular disease, wherein said subject is not a chronic renal failure patient or a dialysis patient, by performing the following steps (i) and (ii):
- (i) capturing, on a solid phase, an extracellular vesicle derived from a blood sample collected from the subject;
- and
- (ii) measuring alkaline phosphatase activity of the extracellular vesicle,
- wherein a measured result of the alkaline phosphatase activity is an index of the onset risk of cardiovascular disease in the subject, wherein when the measured result of the alkaline phosphatase activity is equal to or higher than a predetermined threshold value, the subject is identified as having or at risk of developing cardiovascular disease;
- and
- treating the identified subject by a treatment comprising antihypertensive therapy and/or a medicine suitable for treating cardiovascular disease.
A method for determining vascular calcification in a subject, the method comprising:
- identifying a subject having vascular calcification, wherein said subject is not a chronic renal failure patient or a dialysis patient, by performing the steps (i) and (ii):
- (i) capturing, on a solid phase, an extracellular vesicle derived from a blood sample collected from the subject;
- and
- (ii) measuring alkaline phosphatase activity of the extracellular vesicle,
- wherein a measured result of the alkaline phosphatase activity is an index of vascular calcification in the subject, wherein when the measured result is equal to or higher than a predetermined threshold value, the subject is identified as having vascular calcification;
- and
- treating the identified subject having vascular calcification by a treatment comprising antihypertensive therapy and/or medicine suitable for treating vascular calcification.
Dependencies are inferred from the claim text.