Biomarkers for predicting multiple sclerosis disease activity
AssigneeOctave Bioscience, 1nc.
InventorsMichael Justin Becich, Victor Michael Gehman, Ferhan Qureshi, William A. Hagstrom, Amal Kamal Katrib, Fatima Rubio da Costa
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Abstract
Disclosed herein are methods for analzying quantitative expression values of biomarkers of a biomarker panel for determining disease activity in a human subject. Further disclosed herein are kits for measuring quantitative expression values of the markers as well as computer systems and software embodiments of predictive models for determining disease activity in human subjects based on the quantitative expression values of the markers.
Claims15
A method for determining multiple sclerosis (MS) disease activity in a subject, the method comprising:
- obtaining or having obtained a dataset comprising expression levels of a plurality of biomarkers, wherein the plurality of biomarkers comprise at least one protein from each of
- biomarker 1, biomarker 2, biomarker 3, biomarker 4, biomarker 5, biomarker 6, biomarker 7, and biomarker 8,
- wherein biomarker 1 is NEFL, MOG, CADM3, or GFAP,
- wherein biomarker 2 is MOG, CADM3, KLK6, BCAN, OMG, or GFAP,
- wherein biomarker 3 is CD6, CD5, CRTAM, CD244, or TNFRSF9,
- wherein biomarker 4 is CXCL9, CXCL10, IL-12B, CXCL11, or GFAP,
- wherein biomarker 5 is OPG, TFF3, or ENPP2,
- wherein biomarker 6 is OPN, OMD, MEPE, or GFAP,
- wherein biomarker 7 is CXCL13, NOS3, or MMP-2, and
- wherein biomarker 8 is GFAP, NEFL, OPN, CXCL9, MOG, or CHI3L1, wherein the at least one protein from each biomarker is different from each other, generating a prediction of multiple sclerosis disease activity by applying a predictive model to the expression levels of the plurality of biomarkers, and
- providing the prediction of multiple sclerosis disease activity for selecting a therapeutic agent(s) or plasma exchange for administering to the subject based on the prediction of multiple sclerosis disease activity in the subject.
Dependencies are inferred from the claim text.