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AssigneesAmyris, Inc., Total Marketing Services
InventorsHanxiao Jiang, Adam Meadows
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The present disclosure relates to the use of a switch for the production of heterologous non-catabolic compounds in microbial host cells. In one aspect, provided herein are genetically modified microorganisms that produce non-catabolic compounds more stably when serially cultured under aerobic conditions followed by microaerobic conditions, and methods of producing non-catabolic compounds by culturing the genetically modified microbes under such culture conditions. In another aspect, provided herein are genetically modified microorganisms that produce non-catabolic compounds more stably when serially cultured in the presence of maltose followed by the reduction or absence of maltose, and methods of producing non-catabolic compounds by culturing the genetically modified microbes under such culture conditions.
A fermentation composition comprising a population of genetically modified host cells in a culture medium comprising a carbon source, wherein the host cells comprise:
A fermentation composition comprising a population of genetically modified host cells in a culture medium comprising a carbon source, wherein the host cells comprise:
A fermentation composition comprising a population of genetically modified host cells in a culture medium comprising a carbon source, wherein the host cells comprise:
Dependencies are inferred from the claim text.