Composition for culturing peripheral blood monocyte-derived regulatory t cell and regulatory T cell culturing method using same
AssigneeImmunisbio Co., Ltd.
InventorsSung Hwan Hwang, Jung Hwa Kang
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Abstract
A composition for culturing peripheral blood monocyte-derived regulatory T cells includes at least one antibody selected from the group consisting of anti-CD2, anti-CD3, anti-CD7, anti-CD8, anti-CD28, anti-CD30L, anti-CD40, anti-CD70, anti-CD80, anti-CD83, and anti-CD86; at least one cytokine selected from the group consisting of interleukin-2, interleukin-4, interleukin-7, interleukin-12, interleukin-15, interleukin-34, and TGF-β; and superoxide dismutase. A regulatory T cell culturing method using this composition is also provided. The regulatory T cells according obtained by this method can be utilized for treatment of autoimmune diseases.
Claims2
A composition for inducing the differentiation of regulatory T cells from peripheral blood mononuclear cells, comprising a combination of anti-CD28 antibody, interleukin-2, superoxide dismutase, and myricetin, as a differentiation inducer.
A kit for inducing the differentiation of regulatory T cells from peripheral blood mononuclear cells, comprising a combination of anti-CD28 antibody, interleukin-2, superoxide dismutase, and myricetin, as a differentiation inducer.
Dependencies are inferred from the claim text.