Anti-TIE2 antibody and use thereof

An antibody or an antigen-binding fragment thereof specifically binding to TIE-2 (tyrosine-protein kinase receptor) comprising:

• a heavy-chain variable region comprising a heavy-chain CDR1 of SEQ ID NO:
• 1, a heavy-chain CDR2 of SEQ ID NO:
• 2 and a heavy-chain CDR3 of SEQ ID NO:
• 3, and a light-chain variable region comprising a light-chain CDR1 of SEQ ID NO:
• 4, a light-chain CDR2 of SEQ ID NO:
• 5 and a light-chain CDR3 of SEQ ID NO:
• 6;
• a heavy-chain variable region comprising a heavy-chain CDR1 of SEQ ID NO:
• 7, a heavy-chain CDR2 of SEQ ID NO:
• 8 and a heavy-chain CDR3 of SEQ ID NO:
• 9, and a light-chain variable region comprising a light-chain CDR1 of SEQ ID NO:
• 10, a light-chain CDR2 of SEQ ID NO:
• 11, and a light-chain CDR3 of SEQ ID NO:
• 12;
• a heavy-chain variable region comprising a heavy-chain CDR1 of SEQ ID NO:
• 13, a heavy-chain CDR2 of SEQ ID NO:
• 14 and a heavy-chain CDR3 of SEQ ID NO:
• 15, and a light-chain variable region comprising a light-chain CDR1 of SEQ ID NO:
• 16, a light-chain CDR2 of SEQ ID NO:
• 17, and a light-chain CDR3 of SEQ ID NO:
• 18;
• a heavy-chain variable region comprising a heavy-chain CDR1 of SEQ ID NO:
• 19, a heavy-chain CDR2 of SEQ ID NO:
• 20 and a heavy-chain CDR3 of SEQ ID NO:
• 21, and a light-chain variable region comprising a light-chain CDR1 of SEQ ID NO:
• 22, a light-chain CDR2 of SEQ ID NO:
• 23, and a light-chain CDR3 of SEQ ID NO:
• 24;
• a heavy-chain variable region comprising a heavy-chain CDR1 of SEQ ID NO:
• 25, a heavy-chain CDR2 of SEQ ID NO:
• 26 and a heavy-chain CDR3 of SEQ ID NO:
• 27, and a light-chain variable region comprising a light-chain CDR1 of SEQ ID NO:
• 28, a light-chain CDR2 of SEQ ID NO:
• 29, and a light-chain CDR3 of SEQ ID NO:
• 30;
• or
• a heavy-chain variable region comprising a heavy-chain CDR1 of SEQ ID NO:
• 31, a heavy-chain CDR2 of SEQ ID NO:
• 32 and a heavy-chain CDR3 of SEQ ID NO:
• 33, and a light-chain variable region comprising a light-chain CDR1 of SEQ ID NO:
• 34, a light-chain CDR2 of SEQ ID NO:
• 35, and a light-chain CDR3 of SEQ ID NO:
• 36.