Back to results
US 12,473,336 B2Granted
Methods for activation and expansion of natural killer cells and uses thereof
AssigneeBoard of Regents, The University of Texas System
InventorsLucila Nassif Kerbauy, Elizabeth Shpall, Katy Rezvani
Life of this patent
Estimating the term…
Abstract
Provided herein are methods for pre-activating and expanding an isolated population of NK cells. Further provided herein are methods for the treatment of cancer by administering the pre-activated and expanded NK cells.
Claims16
An in vitro method for expanding natural killer (NK) cells comprising:
- (a) pre-activating a population of cord blood (CB) NK cells in a pre-activation culture comprising an effective concentration of IL-12, IL-15, and IL-18 to obtain pre-activated NK cells;
- and then
- (b) expanding the pre-activated NK cells in an expansion culture comprising artificial antigen presenting cells (aAPCs) expressing CD137 ligand, thereby producing expanded NK cells,
- wherein the expanded NK cells display enhanced antibody-dependent cellular cytotoxicity (ADCC) when compared with a control.
1 more element
Dependencies are inferred from the claim text.