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US 12,473,307 B2Granted
Method of preparing zirconium-89 oxine complex
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsNoriko Sato, Haitao Wu, Gary L. Griffiths, Peter L. Choyke
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Abstract
The invention provides a method of preparing a 89Zr-oxine complex of the formula The invention also provides a method of labeling a cell with the 89Zr-oxine complex and a method for detecting a biological cell in a subject comprising administering the 89Zr-oxine complex to the subject.
Claims2
A method of preparing a 89Zr-oxine complex of the formula comprising
- (i) combining a solution of oxine in hydrochloric acid and a solution of 89ZrCl4 in hydrochloric acid at a temperature of 16° C. to 26° C., in the presence of a surfactant, which is polysorbate 80, to form a reaction mixture,
- (ii) adding an alkaline solution to the reaction mixture in an amount effective to neutralize the mixture, thereby forming the 89Zr-oxine complex, and
- (iii) extracting the 89Zr-oxine complex into chloroform to isolate the 89Zr-oxine complex.
Dependencies are inferred from the claim text.