Compound having neuroprotective effect, preparation method therefor and use thereof

The compound of formula I or a stereoisomer, or a pharmaceutically acceptable salt thereof:

• wherein,
• R1 and R3 are chlorine;
• R2, R4, R5, R5′, R6, R6′, R7, R8 and R9 are hydrogen;
• X is
• W is O;
• m is 1;
• n is 0;
• Z is N;
• Y is COOR15 or CONR16R17;
• R15, R16, and R17 are each independently selected from the group consisting of hydrogen, C1-6 alkyl, C3-8 cycloalkyl, C6-10 aryl, 3-15 membered saturated or unsaturated heterocycloalkyl or heteroaryl containing one or more heteroatoms selected from N, S or O, and —(C1-6 alkylene)(3-15 membered saturated or unsaturated heterocycloalkyl or heteroaryl containing one or more heteroatoms selected from N, S or O);
• the alkyl, cycloalkyl, aryl, heteroaryl and heterocycloalkyl are optionally substituted by one or more substituents selected from the group consisting of hydroxyl, C1-6 alkylene hydroxyl, —NR20R21, C2-6 alkynyl, C2-6 alkenyl, C1-6 alkyl, C3-8 cycloalkyl, 3-8 membered heterocycloalkyl containing one or more heteroatoms selected from N, S or O unsubstituted or substituted by C1-6 alkyl, halogenated C1-6 alkyl, C1-6 alkyl substituted by amino and carboxyl, C1-6 alkoxy, and —COO(C1-6 alkyl);
• and
• R20 and R21 are independently hydrogen or C1-6 alkyl.