Chromatography system and couplings therefor

A chromatography system comprising plural fluid handling components fluidically interconnectable by fluid tubing to form a bioprocess fluid flow path, said fluid handling components comprising one or more fluid ports with a spigot extending from a component face and configured to receive a respective end of the fluid tubing such that the fluid tubing end sealingly embraces the spigot and for receiving a releasable locking clamp thereon for applying a radial locking force on an outer surface of the tubing end for locking the end of the fluid tubing on the spigot, characterised in that an interconnection between the plural fluid handling components withstands at least 10 bar, and wherein the releasable locking clamp comprises:

• a cylindrical inner component for accepting the fluid tubing, said inner component including a resiliently deflectable portion arranged to urge the outer surface of the fluid tubing toward a respective spigot;
• and
• a locking component having an internal through-aperture for accepting the inner component, the through-aperture and resiliently deflectable portion having complementary surface formations which in a first position of the locking component mounted to the inner component provide for resilient deflection in use, and which in a second different position do not cause said deflection,
• wherein the spigot comprises an open end,
• wherein a clamping force is applied on the resiliently deflectable portion of the inner component in the first position of the locking component,
• wherein the clamping force is generated by a movement of the locking component along the inner component towards the opposite direction as the open end of the spigot, and
• wherein the inner component extends beyond the locking component in the same direction as the open end of the spigot in both the first and second positions.