Accelerating cutaneous healing utilizing non-invasive focused ultrasound

A system for promoting cutaneous wound healing, comprising:

• a function generator configured to produce a pulsed sinusoidal waveform;
• an RF power amplifier configured to amplify the pulsed sinusoidal waveform;
• a matching network configured to receive the amplified pulsed sinusoidal waveform;
• and
• a transducer connected to the matching network and configured to generate focused ultrasound pulses based upon the amplified pulsed sinusoidal waveform;
• wherein the system is configured to, upon placement of the transducer at an external stimulation site of a subject, direct focused ultrasound pulses toward a target anatomic site that is on or within an internal organ, wherein the target anatomic site contains or regulates resident or circulating immune cells;
• and
• wherein modulation of the target anatomic site of the subject causes migration of one or more of monocytes, macrophages, or neutrophils to a wound bed of a cutaneous wound.

A method of promoting cutaneous wound healing, comprising:

• positioning an ultrasound transducer at a stimulation site on a subject having a cutaneous wound;
• non-invasively applying pulsed focused ultrasound (pFUS) using the transducer to cause modulation of a target anatomic site that is on or within an internal organ, wherein the target anatomic site contains or regulates resident or circulating immune cells;
• and
• wherein modulation of neurons within the target anatomic site causes a phenotype change of one or more of leukocytes, monocytes, macrophages, or neutrophils that alter healing of a distal wound bed of the cutaneous wound.