Gradient optimized radial treatment (GORT)

A method comprising:

• a. effective and deliberate targeting to non-invasively deliver ionizing, ablating, kV electromagnetic energy beams to specific volumes of tissue or locations inside a body or head, wherein the energy targeting is measured and evaluated in real time with imaging, fiducial localization or other functional registration, wherein the effective and deliberate targeting is as measured by dosimetric conformity consistent with less side effects and better tumor control;
• b. wherein the ionizing kV energy output is effectively directed according to optimized dose gradient vectors towards a desired location, specific or selected volume, and energy waves traveling towards undesired locations, such as healthy tissue, are quenched, wherein the dose delivered to the lesion is at least equal to or greater than the dose to the skin;
• c. obtaining an original condition, state, conformation, functionality or phase in the body by introducing adequate localized energy to a pathologically altered tissue, network or system, sufficient to cause necrosis, induction of apoptosis, induction of heat-shock proteins, decreased blood flow, increased permeability of the blood-brain barrier (BBB), initiating immune responses, or causing euphemistic electromagnetic or chemical interactions;
• d. wherein the energy is focused, enhanced and localized energy, and reverses or destroys malignant tissue thereby enabling restoration to their native, normal conformation;
• e. wherein the beams' variables and parameters, which are optimized for a three-dimensional gradient field, include but are not limited to, energy, spectrum, filtration, field size, location and orientation in stereotactic space or volume, source-to-skin distance (SSD), generating amperage (mA) and time of delivery, beam shape and collimation, and number and location of beam overlaps, consideration of attenuation for a given beam energy and effects of the inverse square law (1/r{circumflex over ( )}2) and inverse cube law (1/r{circumflex over ( )}3);
• f. wherein the variables and parameters of the focused, enhanced and localized ionizing dose or other energy deposition are optimized as gradient vectors or gradient vector fields;
• g. wherein the multiple beams, considered as radial vectors or steradian-associated vectors herein, are focused towards a location targeted in space and time, to deliver effective low-energy ionizing teletherapy as measured by the ability to treat lesions located more than 1 cm beneath the skin surface;
• h. inducing a salutary effect in a diseased tissue comprising a combination of:
• enhancing degradation;
• elimination;
• enhancing immune processing;
• and antigen presentation of peptide elements;
• and
• i. wherein the induced effects of focused, enhanced and localized ionizing energy deposition further comprise a combination of enhancing tissue repair;
• and removing tumors internally, each treating a diseased tissue selected from the group consisting of the head, body and other anatomy.