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US 12,472,289 B2Granted
Heart valve that includes coating material
AssigneeMiRus LLC
InventorsJordan Bauman, Noah Roth, Jay Yadav, S. Beckett Gookin, Md Tausif Salim, Jorge Jimenez, Jason White
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Abstract
A prosthetic heart valve that is at least partially coated with an enhancement layer, and a method for inserting the prosthetic heart valve in a patient. The prosthetic heart valve includes an expandable frame, a leaflet structure, and optionally an inner skirt and/or an outer skirt. One or more of the components of the prosthetic heart valve can be partially or fully coated with the enhancement layer. One type of enhancement layer that can be used includes titanium oxynitride or titanium nitride oxide (TiNOx) and/or zirconium oxynitride (ZrNxOy).
Claims27
A prosthetic heart valve that includes a plurality of components;
- two of said components include a plastically deformable and/or elastically deformable expandable metallic frame and at least one leaflet;
- said metallic frame is directly or indirectly attached to said at least one leaflet;
- said at least one leaflet is configured to at least partially control blood flow through said metallic frame when said prosthetic heart valve is positioned in a heart;
- an outer surface of at least one component of said prosthetic heart valve includes an enhancement coating;
- said enhancement coating is formulated to promote generation of nitric oxide when said prosthetic heart valve is implanted in the heart;
- said enhancement coating is formed of a) a coating material of titanium oxynitride and/or zirconium oxynitride that is directly coated on an outer surface of at least a portion of said metallic frame and/or at least a portion of an outer surface of said at least one leaflet, or b) a metallic adhesion layer and said coating material, and wherein said metallic adhesion layer is directly coated on at least a portion of said outer surface of said metallic frame and/or at least a portion an outer surface of said at least one leaflet, and wherein said metallic adhesion layer is a layer of metal of titanium, titanium alloy, zirconium or zirconium alloy, and wherein said coating material is coated on at least a portion of an outer surface of said metallic adhesion layer, and wherein said enhancement coating is coated on or over at least a portion of an outer surface of said metallic frame and said at least one leaflet, and wherein said coating material is titanium oxynitride and/or zirconium oxynitride.
3 more elements
A method for repairing a heart valve;
- said method comprising:
- a. providing a prosthetic heart valve that is crimped about a delivery system;
- said prosthetic heart valve includes a plurality of components;
- two of said components include a plastically deformable and/or elastically deformable expandable metallic frame and at least one leaflet;
- said metallic frame is directly or indirectly attached to said at least one leaflet;
- said at least one leaflet is configured to at least partially control blood flow through said metallic frame when said prosthetic heart valve is positioned in a heart;
- an outer surface of at least one component of said prosthetic heart valve includes an enhancement coating that has been coated on said outer surface;
- said enhancement coating is formulated to promote generation of nitric oxide when said prosthetic heart valve is implanted in the heart;
- said enhancement coating is formed of a) a coating material of titanium oxynitride and/or zirconium oxynitride that is directly coated on an outer surface of at least a portion of said metallic frame and/or at least a portion of an outer surface of said at least one leaflet, or b) a metallic adhesion layer and said coating material, and wherein said metallic adhesion layer is directly coated on at least a portion of said outer surface of said metallic frame and/or at least a portion an outer surface of said at least one leaflet, and wherein said metallic adhesion layer is a layer of metal of titanium, titanium alloy, zirconium or zirconium alloy, and wherein said coating material is coated on at least a portion of an outer surface of said metallic adhesion layer, and wherein said enhancement coating is coated on or over at least a portion of an outer surface of said metallic frame and said at least one leaflet, and wherein said coating material is titanium oxynitride and/or zirconium oxynitride;
- b. positioning said prosthetic heart valve in a treatment area of said heart;
- and,
- c. expanding said metallic frame from a crimped state to an expanded state while said prosthetic heart valve is in said treatment area of said heart;
- and
- wherein said coating material promotes generation of nitric oxide at or near said treatment area.
11 more elements
Dependencies are inferred from the claim text.